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Symposium: Usefulness and Development of Simple Diagnostic Tools in clinical toxicology, continued


May 30, 2013 2:00pm ‐ May 30, 2013 3:30pm


Credits: None available.

Description

Learning Objectives:

  • Can you discuss the usefulness of a urine test for amatoxins in Amanita poisoning and the problem of false negative tests
  • Can you discuss the correlation of concentration of amatoxin with severity of poisoning
  • Can you contrast the usefulness of urine and blood tests in diagnosis of Amanita poisoning
  • Can you describe the use of determination of amatoxins in therapy and the relevance of liver enzymes
  • Can you describe the reactivation of organophosphorus compound (OP) inhibited acetylcholinesterase including the fact that it is dependent on the properties of the OP, the oximes and the species
  • Can you discuss the fact that effective reactivation can be assumed when activity of the inhibited erythrocyte actelycholinesterase increases substantially after oxime administration
  • Can you describe how reactivation can be prevented by aging, a high poison load and by properties of the OP
  • Can you summarise how an on-site laboratory test system is available which allows prompt determination of erythrocyte acetylcholinesterase, butyrylcholinesterase, reactivatability of OP inhibited actelycholinesterase and presence of inhibitory material (equivalent of poison)
  • Can you describe how the use of this laboratory test system allows on-line monitoring of therapeutic effectiveness of oximes thereby enabling optimized patient oriented oxime treatment
  • Can you report on on-site analysis drug testing for illicit or licit drugs or classes of drugs in urine samples
  • Can you recognise discrepant results for some drugs (cannabinoids, cocaine...) - rapid tests versus both immunoassays and chromatography mass spectrometry methods
  • Can you evaluate new drugs (synthetic cannabinoids, bath salts) not found with immunologic screening
  • Can you describe when rapid tests may be recommended
  • Can you outline the limitations of assays used at the bedside and the use of confirmatory laboratory analysis to identify the different analytes from a drug family e.g. for opiates
  • Can you describe clinical symptoms caused by carbon monoxide (CO) exposure at different ambient air concentration levels and exposure times
  • Can you describe appropriate preclinical and clinical medical treatment measures for CO poisonings
  • Can you state and explain typical CO occupational threshold limit values
  • Can you recognize the typical sources/scenarios of hidden CO release at deployment locations for emergency medical service personnel
  • Can you state and evaluate CO level alarm limits for emergency medical service personnel at deployment locations

Speaker(s):

Speaker(s):

Credits

Credits: None available.

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