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Symposium: The Toxicology of Ethanol


May 31, 2013 10:30am ‐ May 31, 2013 12:00pm


Credits: None available.

Description

Learning Objectives:

  • Can you define what constitutes a standard drink, and relate the number of standard drinks per day and per week that define moderate versus binge drinking
  • Can you describe the differences in prevalence of alcohol use by gender and by age
  • Can you list the impact acute alcohol intoxication has on motor vehicle accidents, falls, drowning; and the alcohol level commonly associated with alcohol poisonings
  • Can you describe the worldwide increased mortality caused by alcohol abuse
  • Can you describe the different toxicokinetic models for the evolution of blood ethanol concentrations
  • Can you list the main factors affecting the ethanol absorption rates by all routes
  • Can you discuss the individual differences in ethanol distribution related to total body water because of factors such as age, sex and obesity
  • Can you explain the relevance of genetic polymorphisms in ADH/ALDH and CYP2E1 enzymatic systems, and of CYP2E1 induction
  • Can you describe the potency of new in silico models for understanding and interpreting ethanol kinetics
  • Can you define toxicodynamic tolerance
  • Can you explain the extent of toxicodynamic tolerance in different populations
  • Can you distinguish between acute and chronic toxicodynamic tolerance
  • Can you describe the Mellanby effect and the function of the GABA receptor
  • Can you describe alterations to metabolism of cocaine in the presence of ethanol and implications for alterations in toxicokinetics and toxicodynamics
  • Can you evaluate predisposition to hepatotoxicity for mixed ingestions of acetaminophen and ethanol
  • Can you identify mixed acute poisonings with ethanol which predispose to disulfiram-like effects

Speaker(s):

Credits

Credits: None available.

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