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Pharmacology for Toxicologists - Part 1


May 26, 2015 9:00am ‐ May 26, 2015 12:30pm


Credits: None available.

Description

Learning Objectives:

  • Describe a dose-effect and dose-toxicity relationship.
  • Estimate the therapeutic range of a given drug.
  • Define intrinsic and idiosyncratic toxicants.
  • Describe the characteristics of different administration routes (oral, intravenous, inhalation, transdermal, etc.).
  • Anticipate the influence of physicochemical properties of a drug on its absorption from different sites of administration.
  • Understand how oral bioavailability (absorption and first-pass effect) are influenced by drug-drug interactions in pharmacology and toxicology.
  • Identify the main transporters expressed in human tissues involved in drug disposition (intestine, liver, kidneys, brain barriers).
  • Recognize significant clinical drug-drug interactions mediated by human drug transporters.
  • Describe FDA and EMA guidelines regarding drug-drug interactions for a new medicine compound that interact with drug transporters and be able to use decisional trees.
  • Explain the underlying mechanisms of phase I and II metabolism.
  • Discuss the most important enzymes involved in phase I and II metabolism.
  • Describe possible clinical and toxicological consequences of genetic polymorphism of drug metabolizing enzymes.
  • Describe normal physiological processes that influence the excretion of xenobiotics and their metabolites.
  • Discuss the influence of impaired kidney and biliary function on the disposition of xenobiotics and their metabolites.
  • List examples of therapeutic interventions that influence xenobiotic excretion in the poisoned patient.
  • Recognize the difference between pharmaco-/toxicokinetics and -dynamics and understand how the two interact.
  • Discuss the different approaches in modelling kinetics and dynamics of xenobiotics.
  • Explain how to interpret data on dose-concentration-response data and how to use them in risk assessment.

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Credits

Credits: None available.

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